Aspergillus Galactomannan ELISA Ikhithi yokubona

Inkqubo echanekileyo yovavanyo lwe-GM ye-EIA yokubhaqa i-Aspergillosis e-Invasive

Izinto zokubhaqa Aspergillus spp.
Indlela yokusebenza I-Enzyme edityaniswe ne-Immunosorbent Assay (ELISA)
Uhlobo lwesampuli Serum, BAL ulwelo
Iinkcukacha Iimvavanyo ezingama-96/ikhithi
Ikhowudi yemveliso FGM096-001

Iinkcukacha zeMveliso

Iithegi zeMveliso

Intshayelelo yeMveliso

I-FungiXpert® Aspergillus Galactomannan ELISA Detection Kit yi-Enzyme-linked immunosorbent assay ukuze kufunyanwe umgangatho we-Aspergillus galactomannan antigen kwisampulu zeserum yabantu abadala kunye nabantwana kunye neesampulu zolwelo lwe-bronchoalveolar lavage (BAL).

Isiganeko se-Invasive Aspergillosis (IA) kwizigulana ezikhuselweyo zikhula ngokukhawuleza ngenxa yokusetyenziswa kakubi kwe-antibiotic.I-IA inezinga eliphezulu lokusweleka ngenxa yokunqongophala kokubonakaliswa kweklinikhi eqhelekileyo kunye neendlela ezisebenzayo zokuxilongwa kwangoko.I-Aspergillus fumigatus yenye yezona zifo zixhaphakileyo ezibangela usulelo olunzima lwe-aspergillus kwizigulane ezine-immunosuppressive disease, ilandelwa yi-Aspergillus flavus, i-Aspergillus niger kunye ne-Aspergillus terreus.

Iimpawu

Igama

Aspergillus Galactomannan ELISA Ikhithi yokubona

Indlela

ELISA

Uhlobo lwesampuli

Serum, BAL ulwelo

Inkcazo

Iimvavanyo ezingama-96/ikhithi

Ixesha lokubona

2 h

Izinto zokubhaqa

Aspergillus spp.

Uzinzo

Ikhithi izinzile unyaka o-1 kwi-2-8 ° C

Umda wokubona ophantsi

0.5 ng/mL

ELISA

Imvelaphi

IAspergillosis ehlaselayo (IA)

Ngoobani abasesichengeni

Izigulana ezine-neutropenia ende, ezilandela ukutshintshwa okanye ngokubambisana nerejimeni ezihlaselayo ze-immunosuppressive.

Izehlo eziphezulu

I-5% ukuya kwi-20%, kuxhomekeke kuluntu lwezigulane.

Izinga eliphezulu lokusweleka

I-50% ukuya kwi-80% ngenxa yenxalenye yokukhula ngokukhawuleza kosulelo (okt, iiveki ezi-1-2 ukusuka ekuqaleni ukuya ekufeni).

Kunzima ukuxilonga

Kunzima ukufumana ubungqina bembali.Uvakalelo lwenkcubeko luphantsi.≈ 30% yamatyala ahlala engafunyaniswanga kwaye enganyangwa ekufeni.

Uvavanyo lweGalactomannan (GM).

  • I-antigen ethile ye-aspergillus efunyenwe kudonga lweseli ekhutshwa ngexesha lokukhula kwe-aspergillosis ehlaselayo.
  • Iintsuku ezisi-7 ukuya kwezili-14 phambi kokuba ezinye iimpawu zokuxilonga zibonakale.

Umgaqo

Aspergillus Galactomannan ELISA Ikhithi yokubona 1

Iingenelo

  • I-Advance engakumbi
    Indlela yokufumanisa edge yamazwe ngamazwe, uvakalelo oluphezulu kunye neenkcukacha
  • Ichaneke ngakumbi
    Lungiselela inkqubo yokusebenza.Ukunciphisa umngcipheko wosulelo ngexesha lovavanyo
  • Ngesantya
    Ukufumanisa inyathelo elinye, ukunciphisa inani le-incubation kunye nexesha lokuhlamba
  • EzoQoqosho ngakumbi
    Ukwahlula i-microplate, ukonga iindleko
  • Iingcebiso
    Inconywe ngumgaqo we-IDSA we-Aspergillosis 2016 kunye ne-ESCMID-ECMM-ERS isikhokelo se-Aspergillosis 2018

Impembelelo yeklinikhi

Ukuxilongwa kwangoko

  • I-GM yi-5-8 iintsuku ngaphambili kuneempawu zeklinikhi ze-aspergillosis (IA);
  • I-GM yi-7.2 iintsuku ngaphambi kokuba isisombululo esiphezulu se-CT scan;
  • I-GM ziintsuku eziyi-12.5 ngaphambi kokuba kuqalwe unyango lwe-antifungal olunamandla.

Ukujongwa okunamandla

  • I-GM ilingana nomlinganiselo wefungus, onokubonisa iqondo lokusuleleka.
  • Umxholo we-antigen we-GM wehla ngokusetyenziswa kweziyobisi ezichasayo.
Aspergillus Galactomannan ELISA Ikhithi yokubona 2

Isiseko sezonyango esibalulekileyo

  • Ukunciphisa ukusetyenziswa konyango lwe-antifungal olunamandla.
  • Ulungelelwaniso olomeleleyo phakathi kwesiphumo kunye nesalathiso se-GM somhlaza we-hematological.

Ukufunyanwa kwe-United yovavanyo lwe-G kunye ne-GM

  • Ukuchaneka okuphezulu kunye nexabiso eliqikelelweyo eliqinisekileyo
  • Uvakalelo oluphezulu

Ulwazi lweodolo

Umzekelo

Inkcazo

Ikhowudi yemveliso

GMKT-01

Iimvavanyo ezingama-96/ikhithi

FGM096-001


  • Ngaphambili:
  • Okulandelayo:

  • Bhala umyalezo wakho apha kwaye uwuthumele kuthi