Aspergillus Galactomannan ELISA Ikhithi yokubona
Intshayelelo yeMveliso
I-FungiXpert® Aspergillus Galactomannan ELISA Detection Kit yi-Enzyme-linked immunosorbent assay ukuze kufunyanwe umgangatho we-Aspergillus galactomannan antigen kwisampulu zeserum yabantu abadala kunye nabantwana kunye neesampulu zolwelo lwe-bronchoalveolar lavage (BAL).
Isiganeko se-Invasive Aspergillosis (IA) kwizigulana ezikhuselweyo zikhula ngokukhawuleza ngenxa yokusetyenziswa kakubi kwe-antibiotic.I-IA inezinga eliphezulu lokusweleka ngenxa yokunqongophala kokubonakaliswa kweklinikhi eqhelekileyo kunye neendlela ezisebenzayo zokuxilongwa kwangoko.I-Aspergillus fumigatus yenye yezona zifo zixhaphakileyo ezibangela usulelo olunzima lwe-aspergillus kwizigulane ezine-immunosuppressive disease, ilandelwa yi-Aspergillus flavus, i-Aspergillus niger kunye ne-Aspergillus terreus.
Iimpawu
| Igama | Aspergillus Galactomannan ELISA Ikhithi yokubona |
| Indlela | ELISA |
| Uhlobo lwesampuli | Serum, BAL ulwelo |
| Inkcazo | Iimvavanyo ezingama-96/ikhithi |
| Ixesha lokubona | 2 h |
| Izinto zokubhaqa | Aspergillus spp. |
| Uzinzo | Ikhithi izinzile unyaka o-1 kwi-2-8 ° C |
| Umda wokubona ophantsi | 0.5 ng/mL |
Imvelaphi
IAspergillosis ehlaselayo (IA)
Ngoobani abasesichengeni
Izigulana ezine-neutropenia ende, ezilandela ukutshintshwa okanye ngokubambisana nerejimeni ezihlaselayo ze-immunosuppressive.
Izehlo eziphezulu
I-5% ukuya kwi-20%, kuxhomekeke kuluntu lwezigulane.
Izinga eliphezulu lokusweleka
I-50% ukuya kwi-80% ngenxa yenxalenye yokukhula ngokukhawuleza kosulelo (okt, iiveki ezi-1-2 ukusuka ekuqaleni ukuya ekufeni).
Kunzima ukuxilonga
Kunzima ukufumana ubungqina bembali.Uvakalelo lwenkcubeko luphantsi.≈ 30% yamatyala ahlala engafunyaniswanga kwaye enganyangwa ekufeni.
Uvavanyo lweGalactomannan (GM).
- I-antigen ethile ye-aspergillus efunyenwe kudonga lweseli ekhutshwa ngexesha lokukhula kwe-aspergillosis ehlaselayo.
- Iintsuku ezisi-7 ukuya kwezili-14 phambi kokuba ezinye iimpawu zokuxilonga zibonakale.
Umgaqo
Iingenelo
- I-Advance engakumbi
Indlela yokufumanisa edge yamazwe ngamazwe, uvakalelo oluphezulu kunye neenkcukacha - Ichaneke ngakumbi
Lungiselela inkqubo yokusebenza.Ukunciphisa umngcipheko wosulelo ngexesha lovavanyo - Ngesantya
Ukufumanisa inyathelo elinye, ukunciphisa inani le-incubation kunye nexesha lokuhlamba
- EzoQoqosho ngakumbi
Ukwahlula i-microplate, ukonga iindleko - Iingcebiso
Inconywe ngumgaqo we-IDSA we-Aspergillosis 2016 kunye ne-ESCMID-ECMM-ERS isikhokelo se-Aspergillosis 2018
Impembelelo yeklinikhi
Ukuxilongwa kwangoko
- I-GM yi-5-8 iintsuku ngaphambili kuneempawu zeklinikhi ze-aspergillosis (IA);
- I-GM yi-7.2 iintsuku ngaphambi kokuba isisombululo esiphezulu se-CT scan;
- I-GM ziintsuku eziyi-12.5 ngaphambi kokuba kuqalwe unyango lwe-antifungal olunamandla.
Ukujongwa okunamandla
- I-GM ilingana nomlinganiselo wefungus, onokubonisa iqondo lokusuleleka.
- Umxholo we-antigen we-GM wehla ngokusetyenziswa kweziyobisi ezichasayo.
Isiseko sezonyango esibalulekileyo
- Ukunciphisa ukusetyenziswa konyango lwe-antifungal olunamandla.
- Ulungelelwaniso olomeleleyo phakathi kwesiphumo kunye nesalathiso se-GM somhlaza we-hematological.
Ukufunyanwa kwe-United yovavanyo lwe-G kunye ne-GM
- Ukuchaneka okuphezulu kunye nexabiso eliqikelelweyo eliqinisekileyo
- Uvakalelo oluphezulu
Ulwazi lweodolo
| Umzekelo | Inkcazo | Ikhowudi yemveliso |
| GMKT-01 | Iimvavanyo ezingama-96/ikhithi | FGM096-001 |
