Ngoku iiseli ezosulelekileyo zigcina i-HIV-1 proviral DNA genome edityaniswe ikakhulu kwi-heterochromatin, evumela ukuzingisa kwee-proviruses ezingathethiyo ngokubhaliweyo.I-Hypoacetylation yeeprotheni ze-histone nge-histone deacetylases (i-HDAC) ibandakanyeka ekugcinweni kwe-HIV-1 latency ngokucinezela i-viral transcription.Ukongeza, izifo ze periodontal, ezibangelwa yi-polymicrobial subgingival bacteria kuquka i-Porphyromonas gingivalis, ziphakathi kosulelo oluxhaphakileyo eluntwini.Apha sibonisa iziphumo ze-P. gingivalis kuphindaphindo lwe-HIV-1.Lo msebenzi unokubalelwa kwinkcubeko yebhaktiriya ephezulu kodwa hayi kwezinye iinxalenye zebhaktiriya ezifana ne-fimbriae okanye i-LPS.Siye safumanisa ukuba lo msebenzi wokwenza i-HIV-1 uphinde wafunyanwa kubunzima obusezantsi bemolekyuli (<3 kDa) iqhezu lenkcubeko enamandla kakhulu.Siphinde sabonisa ukuba i-P. gingivalis ivelisa i-acids ephezulu ye-butyric, esebenza njenge-inhibitor enamandla ye-HDACs kwaye ibangela i-histone acetylation.I-Chromatin immunoprecipitation assays ibonise ukuba i-corepressor complex equlethe i-HDAC1 kunye ne-AP-4 yahlulwe kwi-HIV-1 ye-terminal ephinda umgqugquzeli ende ekuvuseleleni inkcubeko ye-bacterial supernatant kunye nombutho we-acetylated histone kunye ne-RNA polymerase II.Ngoko ke sifumanise ukuba i-P. gingivalis inokuphembelela ukuvuselelwa kwe-HIV-1 ngokuguqulwa kwe-chromatin kwaye i-asidi ye-butyric, enye ye-metabolites yebhaktiriya, inoxanduva lwesi siphumo.Ezi ziphumo zibonisa ukuba izifo ze periodontal zinokusebenza njengomngcipheko wokuvuselelwa kwe-HIV-1 kubantu abosulelekileyo kwaye zinokuba negalelo ekusasazeni intsholongwane ngokwenkqubo.
Ixesha lokuposa: Sep-10-2020