Ngaba (1-3)-β-D-glucan iNxulumano elahlekileyo ukusuka kuVavanyo olusecaleni kwebhedi ukuya kuNyango lwangaphambili lwe-Invasive

I-candidiasis ehlaselayo yingxaki ehlala ibeka ubomi kwizigulane ezigula kakhulu.Ukuxilongwa kwangoko okulandelwa lunyango olukhawulezileyo olujolise ekuphuculeni isiphumo ngokunciphisa ukusetyenziswa kwe-antifungal ngokungeyomfuneko kuhlala kungumngeni omkhulu kwisimo se-ICU.Ukukhethwa kwezigulane ngexesha ke ngoko kudlala indima ephambili kulawulo olusebenzayo lweklinikhi kunye noluneendleko ezifanelekileyo.Iindlela ezidibanisa izinto ezinobungozi beklinikhi kunye neenkcukacha ze-Candida colonization ziye zaphucula amandla ethu okuchonga izigulane ezinjalo kwangoko.Ngelixa ixabiso elibi lokuxela kwangaphambili lamanqaku kunye nemithetho yokubikezela ifikelela kwi-95 ukuya kwi-99%, ixabiso eliqikelelweyo elihle liphantsi kakhulu, liphakathi kwe-10 kunye ne-60%.Ngokufanelekileyo, ukuba amanqaku afanelekileyo okanye umthetho usetyenziswa ukukhokela ukuqaliswa konyango lwe-antifungal, izigulane ezininzi zinokunyangwa ngokungeyomfuneko.Iimpawu zebhayoloji zeCandida zibonisa amaxabiso aqikelelweyo aphezulu;nangona kunjalo, abanalo uvakalelo kwaye ngoko abakwazi ukuchonga zonke iimeko ze-candidiasis ehlaselayo.Uvavanyo (1-3) -β-D-glucan (BG), uvavanyo lwe-panfungal antigen, lunconywa njengesixhobo esongezelelweyo sokuxilongwa kwe-mycoses eyingozi kwizigulane ze-hemato-oncological.Indima yayo kuluntu oluninzi lwe-ICU isaza kuchazwa.Izicwangciso ezisebenzayo zokukhetha iikliniki ezidibeneyo kunye nezixhobo zebhubhoratri ezisebenzayo ziyafuneka ukwenzela ukunyanga izigulane ezifanelekileyo ngexesha elifanelekileyo ngokugcina iindleko zokuhlola kunye nonyango oluphantsi kangangoko kunokwenzeka.Indlela entsha ecetywayo yiPosteraro kunye noogxa kwinqaku langaphambili le-Critical Care ihlangabezana nezi mfuno.Ixabiso elilodwa elihle le-BG kwizigulane zonyango ezingeniswe kwi-ICU kunye ne-sepsis kwaye kulindeleke ukuba zihlale ngaphezu kweentsuku ze-5 zandulela ukubhalwa kwe-candidemia nge-1 kwiintsuku ze-3 ngokuchaneka okungakaze kubonwe ngaphambili.Ukusebenzisa le ngongoma enye yokuhlolwa kwefungal kwi-subset ekhethiweyo yezigulane ze-ICU kunye noqikelelo lwe-15 ukuya kwi-20% yomngcipheko wokuphuhlisa i-candidemia yindlela ekhangayo kwaye enokuthi ibe neendleko.Ukuba iqinisekiswa luphando lwamaziko amaninzi, kwaye yandiswe kwizigulane zotyando ezisengozini enkulu ye-candidiasis ehlaselayo emva kokuhlinzwa kwesisu, le ndlela ye-Bayesian-based stratification yomngcipheko ejoliswe ekwandiseni ukusebenza kakuhle kwekliniki ngokunciphisa ukusetyenziswa kwezibonelelo zempilo inokwenza lula ulawulo lwezigulane ezisengozini. kwi-candidiasis eyingozi.