Uphononongo lwamva nje lwamaziko amaninzi malunga nokuxilongwa kosulelo lwe-cryptococcal lwenziwe liZiko lezoNyango leDyunivesithi yase-Utrecht, iZiko leBiodiversity kunye ne-Ecosystem Dynamics leDyunivesithi yaseAmsterdam, iZiko laseWesterdijk leZityalo ezahlukeneyo zeFungal, kunye neMatogro ILebhu yoPhando lweFungi IYunivesithi yaseFederal yaseSomalia kunye neSibhedlele seYunivesithi yaseJúlio Muller yeYunivesithi yaseFederal yaseMato Grosso iqalise ngokudibeneyo kwaye yapapasha isihloko esithi "Ukungahoyi imfuzo yemfuza" kwiJenali yeClinical Microbiology ngoJanuwari 2021. Ukwahluka kuthintela ukuxilongwa ngexesha losulelo lweCryptococcus "inqaku.Eli nqaku lithelekisa iimveliso ezine ze-cryptococcal colloidal zegolide, kwaye ivavanya ukusebenza kokuxilonga kwemveliso nganye kwiintlobo ezahlukeneyo ze-cryptococcal ukusuka kumbono weentlobo ezahlukeneyo zofuzo ze-Cryptococcus neoformans kunye ne-Cryptococcus guttata.Ukubonelela ngesiseko esisebenzayo sokuxilongwa ngokukhawuleza kweklinikhi ye-Cryptococcus.
Iibrendi ezine ze-cryptococcal colloidal gold quick test reagents zisetyenziselwe ukuvavanya uluhlu lweentlobo ezahlukeneyo ezibonisa iyantlukwano yemfuza ye-cryptococcus, kuquka iimveliso zeenkampani ezine kunye neempawu eziquka i-Tianjin FungiXpert® kunye ne-IMMY Diagnostics yase-United States.Iintlobo ezingamashumi amane ze-Cryptococcus ezibandakanya zonke iintlobo ezisixhenxe ezaziwayo kunye nemixube yazo ye-interspecific ziye zavavanywa.
Iziphumo zoPhando:
Iziphumo zophando zibonisa ukuba i-FungiXpert® (i-brand ye-Genobio) kunye ne-IMMY's colloidal gold test card inokubona zonke i-Cryptococcus ezisixhenxe ze-pathogenic.
Xa uvavanya ezinye ezimbini iimveliso zegolide ye-colloidal, ezinye iintlobo ezifana neC. bacillisporus, C. deuterogattii, kunye neC. tetragattii, ngakumbi iC.Nangona kunjalo, usulelo lwe-C. tetragattii luxhaphakile kwi-Afrika ekwi-sub-Saharan nakwilizwekazi lase-Indiya, elinelona nani liphezulu lezehlo ze-cryptococcal meningitis ezinxulumene ne-HIV.Okubalulekileyo, i-13-20% yezehlo ze-cryptococcal meningitis ezinxulumene ne-HIV zinxulumene ne-C. tetragattii.
Ngokujonga iingxelo zamva nje zeziphumo ezingezizo zobuxoki kwiimvavanyo ze-cryptococcal eBotswana nase-Uganda, ababhali bagqibe kwelokuba i-C. tetragattii kungenzeka ukuba ibekho kwiisampulu zophando lweklinikhi ngezi ziphumo zingalunganga.
Isiphelo sohlalutyo:
Umbhali ucebisa ukuba ekusekweni okanye ekuvavanyeni iindlela zokufumanisa i-cryptococcal, i-epidemiology yendawo, imvelaphi yofuzo kunye nentlukwano ye-taxonomic kufuneka ithathelwe ingqalelo.I-Cryptococcus ye-Pathogenic akufanele ikhawulelwe kwi-classification eyodwa ye-AD serotypes.Ukuqwalasela indlela ehlaziyiweyo yokuhlelwa kwe-cryptococcal kuyilo lwemveliso kunye nokuqinisekiswa kunokunciphisa ilahleko yobuntununtunu obubangelwa yi-negatives yobuxoki.
Ikhadi lokufumanisa i-cryptococcal capsular polysaccharide (indlela yegolide ye-colloidal) ephuhliswe kwaye yaveliswa yi-Genobio Pharmaceutical Co., Ltd. ithatha indlela yokufumanisa igolide ye-colloidal, enokuchonga ngokufanelekileyo zonke iintlobo ze-cryptococcal strains.Umsebenzi ulula, kwaye iziphumo ziyaqondakala kwaye ziyasebenza.Emva kokubona iziphumo zovavanyo zinokufumaneka kwimizuzu eli-10!Ukubonelela ngesiseko esithembekileyo sokuxilongwa kwangaphambili kunye nokukhawuleza kwe-Cryptococcus!
Umthombo wenqaku:
Shi D, Haas PJ, Boekhout T, et al.Ukungahoywa kweyantlukwano yemfuza kuthintela ukuxilongwa kwangethuba kosulelo lwe-Cryptococcus[J].Ijenali yeClinical Microbiology, 2021.
Ikhonkco lenqaku:
https://journals.asm.org/doi/10.1128/JCM.02837-20
Ixesha lokuposa: Jul-28-2021