I-Carbapenem-resistant NDM Detection K-Set (Lateral Flow Assay) yinkqubo yokuvavanya i-immunochromatographic ejoliswe ekufumaneni umgangatho we-NDM-uhlobo lwe-carbapenemase kwiikholoni zebhaktheriya.Uvavanyo luvavanyo lwebhubhoratri yokusetyenziswa kwemithi enokuthi incede ekuxilongweni kwe-NDM-uhlobo lwe-carbapenem resistant strains.
Igama | Carbapenem-resistant NDM Fuction K-Set (Lateral Flow Assay) |
Indlela | I-Lateral Flow Assay |
Uhlobo lwesampuli | Iikholoni zebhaktheriya |
Inkcazo | Iimvavanyo ezingama-25/ikhithi |
Ixesha lokubona | 10-15 imiz |
Izinto zokubhaqa | Carbapenem-resistant Enterobacteriaceae (CRE) |
Uhlobo lokufunyanwa | NDM |
Uzinzo | I-K-Set izinzile iminyaka emi-2 ku-2°C-30°C |
Carbapenem-resistant Enterobacteriaceae (CRE) luhlobo lwebhaktheriya.Basenokubangela usulelo oluyingozi olunokuba nzima ukunyanga.I-CRE ifumene igama layo kwinto yokuba ayinyangeki kwi-carbapenems.I-Carbapenems ludidi oluphezulu lwe-antibiotics.Zadalwa ngeminyaka yoo-1980 ukunceda ukunyanga iibhaktheriya ezazingenako ukunyangwa ngamanye amayeza okubulala iintsholongwane.Amayeza okubulala iintsholongwane asetyenziselwa ukubulala iintlobo ezithile zeebhaktheriya.Zininzi iindidi zala mayeza.Ekuhambeni kwexesha, ezinye iintsholongwane zisenokungaphindi zibulawe zizo.Oku kwaziwa njengokunganyangeki ngamayeza okubulala iintsholongwane.Ukusasazeka ngokukhawuleza kwe-CRE kubangelwa ukusetyenziswa kakubi kweziyobisi kunye nokuphathwa kakubi kwezigulane ze-CRE.Ukuba imeko ayihoywanga, iya kuchaphazela kakhulu ukhathalelo lwempilo yabantu, yenze ukuba unyango lweklinikhi kunye nolawulo lwezifo lube nzima ngakumbi.
Indlela eqhelekileyo yokuthintela ukusasazeka kweCRE zezi:
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Kucacile ukubona ukubaluleka kovavanyo lwe-CRE kwangethuba kuzo zonke ezi ndlela zingasentla.Uvavanyo olukhawulezayo noluchanekileyo lokuxilonga lubaluleke kakhulu kuchwethezo lwakwangoko lweentlobo ze-CRE, isikhokelo samayeza, kunye nokuphuculwa kwemigangatho yonyango kunye nezempilo yabantu.
I-Carbapenemase ibhekisela kuhlobo lwe-β-lactamase olunokuthi ubuncinane i-hydrolyze imipenem okanye i-meropenem, kuquka i-A, B, D iintlobo ezintathu ze-enzymes ezihlelwe yi-Ambler isakhiwo se-molecular.Phakathi kwabo, i-Class B yi-metallo-β-lactamases (MBLs), kuquka i-IMP, i-VIM kunye ne-NDM, njl, ebizwa ngokuba yi-metalloenzyme, eyayifumaneka kakhulu kwi-Pseudomonas aeruginosa, i-Acinetobacteria kunye ne-Enterobacteriaceae bacteria.Ukusukela oko yaxelwa okokuqala eIndiya ngo-2008, i-NDM (iNew Delhi metallo-beta-lactamase) isasazeke kwihlabathi jikelele ngesantya esothusayo.Ukuza kuthi ga ngoku, i-NDM ivele kumazwe amaninzi eYurophu, eUnited States, eCanada naseMexico kuMntla Merika, nakumazwe aseAsia anjengeTshayina, iJapan, uMzantsi Korea kunye neSingapore.Kumazwe afana ne-Indiya nePakistan, i-NDM ibangele ubhubhani, ngesantya sokubhaqa se-38.5%.Ukukhupha iimveliso zokuxilonga ezikhawulezayo ze-carbapenemase kubaluleke kakhulu kuchwethezo lwangoko lweentlobo ezinganyangekiyo ngamachiza, isikhokelo samayeza, kunye nokuphuculwa kwemigangatho yezonyango kunye nempilo yabantu.
Umzekelo | Inkcazo | Ikhowudi yemveliso |
I-CPN-01 | Iimvavanyo ezingama-25/ikhithi | I-CPN-01 |